Previous Next Index Thread

Re: Melatonin Users - downregulation?

 Steve Farmer <> wrote:
 >Jason Taylor wrote, re melatonin production:
 >> wrote:
 >> : In article, (Alan Pollock) writes:
 >> : >Actually, according to multitudinous medline reports and from other
 >> : >sources, the pineal gland does Not loose the capacity to produce
 >> : >melatonin, nor does it ever stop producing it whilst supplements 		 
 >     are [being given].
 >> That's great news if true!  I'm a sceptic at heart though, so would
 >> you be so kind as to post the references of the papers which show that
 >> production is independent of serum levels?  Many thanks in advance.
 >I agree with Jason. I've used time-release melatonin (1.8 - 2 mg/night) 
 >for over a year now. I developed signs of tolerance after a few months. 
 >I now use melatonin every *other* night, and so far the strategy has 
 >worked perfectly, at least so far as sleep quality goes. (What all this 
 >means in regard to melatonin's putative anti-aging properties is an open 
 >question). If I try to use melatonin every night, my sleep tends to be 
 >fitful. The same thing happens if I double the dosage. All this suggests 
 >that at a minimum downregulation of melatonin receptors is occurring and 
 >that the hormone has non-linear effects, presumably from negative 
 >feedback controls over endogenous production. Analogy with other 
 >hormones would lead you to suppose that endogenous melatonin production 
 >probably decreases with supplementation as well.
 >Along these lines, I've run across several animal studies in the last 
 >year that suggest that downregulation of melatonin receptors in 
 >particular brain regions *does* take place when animals are given 
 >supplemental melatonin. I'll dig up abstracts of these papers and post 
 >them if anyone is interested in looking at them. I know of no studies - 
 >if anyone else does, please e-mail me - concerning how endogenous 
 >production is affected by supplementation. I hope to write an article on 
 >this question in a future issue of _Narcolepsy & Sleep Disorders_, which 
 >I often write for. 
 >Steve Farmer
 Oh Steve Farmer,  your such a charm! Now it's melatonin your after-
 and of course next comes DHEA - and then what? Co - enzyme Q10? I see
 a budding career developing for you in the ANTI-ALTERNATIVE MEDICINE
 But please tell me. When do we get around to talking about all those
 caustiic killer drugs that even my doctor hesitates to prescribe. You 
 know -  the ones that are  FDA approved. And maybe we can discuss some
 of the alternatives to those FDA Drugs. Like tell me Steve, What's 
 better than Melatonin? What  effective aid to sleeping has fewer side 
 Ernie Collins
 Ernie Collins